Fructose Metabolism

Q10. What are the enzymes deficiencies in essential fructosuria and hereditary fructose intolerance? Write down reaction catalyzed by these enzymes. Which one leads to severe hypoglycaemia of fructose and why? What is the cause of hyperuricaemia in this condition? (Annual 2008)

In controlled study, one group of albino rats were fed with 20gm glucose and other group with 20gm sucrose daily for six months. In autopsy the sucrose fed rats developed more atherosclerosis than the glucose fed, Explain the mechanism. (Annual 2010)

Q42: a) How high fructose intake for prolonged time is more atherogenic than Glucose? (2017 Annual) b) Give hepatic metabolism of Fructose and its regulation.