Oxidation of Pyruvate

Q21. How pyruvate is converted to acetyl-CoA? Give its regulation. (Annual 2011)

Q28. A Three year old boy presented with neurological disturbances, lactic acidosis and seizures and diagnosed as having pyruvate dehydrogenase complex deficiency. (Supple 2012)

(a) How lactic acidosis occurs in this metabolic defect? (b) Why neurological disturbances occur?

(a) Give different fates of pyruvate. (b) Give different components of PDH complex. (Supple 2016)

Q44: How pyruvate is oxidized to acetyl CoA in mictochondria, give its regulation? (2017 Supple)

(b) A chronic alcoholic has been brought to medical emergency. Blood biochemistry reveal lactic acidosis. Deficiency of pyruvate dehydrogenase complex is suspected. i. Give the reaction catalyzed by pyruvate dehydrogenase complex with its mechanism. ii. Why thiamine deficiency leads to deficiency activity of PDH complex? (2018 Annual)