Hexose Monophosphate Pathway

Q2. What is the significance of hexose- Monophosphate-Pathway? What happens in glucose-6-phosphate dehydrogenase deficiency? (Annual 2005)

Q7. Enumerate functions of pentose phosphate pathway. What are the consequences of glucose- 6-P-dehydrogenase deficiency? (Annual 2007)

Q11. What is the role of glucose-6-PO4 dehydrogenase in RBCs? (Annual 2008)

Q14. Write down reactions catalyzed by G6PD. Why does its deficiency leads to hemolytic anemia. (Annual 2009)

Q23. A person after taking anti-malarial drugs developed severe intravascular hemolysis. Name the deficient enzyme? How hemolysis occurred in RBCs? (Annual 2011)s

Q33. A Patient having high grade fever took antimalarial drugs and aspirin and developed intravascular hemolysis. On investigation, the erythrocyte glucose dehydrogenase activity was markedly low. (Annual 2015) (i) Which metabolic pathway is suppressed in this patient? (ii) How he developed intravascular hemolysis?

Q40. A patient was brought to emergency room with high grade fever and shivering. He was diagnosed as a case of malaria and was given primaquine which produced hemolysis in this patient.The patient diagnosed to have G6PD deficiency.(Supple 2016) (a) What was biochemical cause of hemolysis in this patient. (a) Write down reaction catalyzed by G6PD.

Q43: Define oxidative and non-oxidative phase of hexose monophosphate pathway, giving importance of each, (2017 Supple)

Q45 a) A patient after taking antimalarial drugs developed severe intravascular hemolysis. Name the enzyme deficient in thispatient. Why deficiency of this enzyme leads to hemolysis? (2018 Annual)

Q46: What is glucose-6-phosphate dehydrogenase (G- 6-PD) deficiency? (2018 Supple)