Glycogen Metabolism

Q3. Outline the steps of breakdown of glycogen. Enlist Glycogen storage diseases. (Supple 2005)

How glycogen is synthesized in the liver? How glycogen synthesis is regulated? What is reciprocal regulation of glycogen metabolism? (Supple 2006)

An old female presents in emergency with hypoglycemia, and hepatomegaly. Lab investigations shows lactic acidosis, hyperuricemia and increased glycogen in cells. Name enzyme deficient. What is biochemical reason for Lactic acidosis and hyperuricemia? (2012)

Q 47 a) A 4 months old infant was brought to the hospital with jittery spells and irritability several hours after feeding. Physical examination revealed enlarged liver. The laboratory reports indicated that he developed fasting hypoglycemia. Large deposits of glycogen with shorter than normal branches vere seen in biopsy specimen from the liver. (2019 Annual) i) What is the probable diagnosis? Name the eficient enzyme. ii) How glycogen synthesis and degradation is allosterically regulated especially in liver and muscle? (2019 Annual) b) How pyruvate, the end product of glycolysis, is converted to acetyl CoA? Give its regulation.